Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes.
نویسندگان
چکیده
doi: 10.3967/bes2015.116 This study is supported by a POSDRU grant, No. 159/1.5/S/136893 grant with title: ‘Parteneriat strategic pentru creşterea calităţii cercetării ştiinţifice din universităţile medicale prin acordarea de burse doctorale şi postdoctorale-DocMed.Net_2.0’. 1. Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babeş, 400012 Cluj-Napoca, Romania; 2. Department of Toxicology, Faculty of Pharmacy, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babeş, 400012 Cluj-Napoca, Romania Letter to the Editor
منابع مشابه
Inhibition of genistein glucuronidation by bisphenol A in human and rat liver microsomes.
Genistein is a natural phytoestrogen of the soybean, and bisphenol A (BPA) is a synthetic chemical used in the production of polycarbonate plastics. Both genistein and BPA disrupt the endocrine system in vivo and in vitro. Growing concerns of altered xenobiotic metabolism due to concomitant exposures from soy milk in BPA-laden baby bottles has warranted the investigation of the glucuronidation ...
متن کاملQuinol-based metabolic cycle for estrogens in rat liver microsomes.
According to a recently reported metabolic pathway, phenolic A-ring estrogens are metabolized in rat liver microsomes partially to the corresponding quinols by cytochrome P450 isoenzymes. We found that these quinols could, in turn, undergo reduction to regenerate the parent estrogens consumed during the metabolic process. Among the tested endogenous reducing agents, NADH and especially NADPH pr...
متن کاملEffects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver
Objective(s): Recognized as a distinguished environmental and global toxicant, Bisphenol A (BPA) affects the liver, which is a vital body organ, by the induction of oxidative stress. The present study was designed to investigate the protective effect of quercetin against BPA in hepatotoxicity in Wistar rats and also, the activity of mitochondrial enzymes were evaluated...
متن کاملMetabolism of flavonoids via enteric recycling: role of intestinal disposition.
The purpose of this study was to determine the importance of intestinal disposition in the first-pass metabolism of flavonoids. A four-site perfused rat intestinal model, rat liver and intestinal microsomes, Caco-2 cell microsomes, and the Caco-2 cell culture model were used. In the four-site model, approximately 28% of perfused aglycones are absorbed (approximately 450 nmol/30 min). Both absor...
متن کاملComparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.
Bisphenol A [BPA, 2,2-bis(4-hydroxyphenyl)propane], a xenoestrogen, is a monomer for the synthesis of polycarbonate plastics, epoxy resins, and composites. Metabolism of BPA to the monoglucuronide will determine the extent of its estrogenicity in vivo. Investigation of the metabolism of BPA (500 microM) by isolated female rat hepatocytes confirmed the formation of BPA glucuronide as the major m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biomedical and environmental sciences : BES
دوره 28 11 شماره
صفحات -
تاریخ انتشار 2015